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Treatment-resistant depression 

Treatment-resistant depression
Chapter:
Treatment-resistant depression
Author(s):

Basant K. Puri

DOI:
10.1093/med/9780199670444.003.0011
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date: 14 December 2019

Treatment-resistant depression

Although there is no generally accepted definition of treatment-resistant depression, NICE defines treatment-resistant depression as that which fails to respond to two or more antidepressants given sequentially at an adequate dose for an adequate time. David Christmas (2011) has published a particularly helpful algorithm to be used for the management of such treatment-refractory depression in primary care. The steps in this algorithm are as follows....

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