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Oral anticoagulation 

Oral anticoagulation
Oral anticoagulation

Freek W. A. Verheugt

, Sam Schulman

, Andrea Rubboli

, Jonathan L. Halperin

, and Gregory Y. H. Lip

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date: 25 November 2020

Oral anticoagulation (OAC) is indicated to prevent the occurrence and/or recurrence of arterial and venous thromboembolism. Oral anticoagulation is a complex treatment requiring appropriate indications and careful management. Vitamin K-antagonists (warfarin, acenocoumarol, phenprocoumon), and newer, non-vitamin K-antagonists direct inhibitors of thrombin (dabigatran) or of factor Xa (rivaroxaban, apixaban) are the oral anticoagulants currently available. Bleeding is the most frequent unwanted effect of oral anticoagulation, and may have important prognostic impact. Stratification of the individual risk of thromboembolism and bleeding is advised prior to starting oral anticoagulation to optimize the risk to benefit ratio.

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