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Multidrug-resistant tuberculosis 

Multidrug-resistant tuberculosis
Chapter:
Multidrug-resistant tuberculosis
Author(s):

Caoimhe Nic Fhogartaigh

DOI:
10.1093/med/9780199665754.003.0029
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date: 21 January 2020

Multidrug-resistant tuberculosis (MDR-TB) is increasingly being identified around the world. Treatment options are limited due to the lack of new anti-mycobacterial agents and the side-effect profiles of currently available options. Diagnosis is dependent on both the ability to perform phenotypic susceptibility testing and increasingly on molecular methodologies. A case of MDR-TB is presented and the management discussed. The side effects suffered by the patient and the concomitant resistance to the fluoroquinolones leads the physicians to apply for compassionate use of TMC 207, a new anti-mycobacterial agent.

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