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Pneumococcal meningitis: antibiotic options for resistant organisms 

Pneumococcal meningitis: antibiotic options for resistant organisms
Chapter:
Pneumococcal meningitis: antibiotic options for resistant organisms
Author(s):

Sathyavani Subbarao

DOI:
10.1093/med/9780199665754.003.0023
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date: 25 February 2020

Pneumococcal meningitis continues to be associated with high rates of mortality and long-term neurological sequelae. Colonization is the first step towards infection, and vaccination has reduced rates of invasive Streptococcus pneumoniae in both adults and children. Although rates of infection with penicillin non-susceptible strains is low in the UK as a whole, certain infections may occur, especially in those who have been living in high-risk areas of the world. The chapter highlights a case of pneumococcal meningitis due to an isolate that is non-susceptible to penicillin and with reduced susceptibility to third-generation cephalosporins. The clinical management of the case including timing of computed tomography and lumbar puncture, and the antibiotic choice in such a patient is discussed.

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