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Meticillin-resistant Staphylococcus aureus bacteraemia 

Meticillin-resistant Staphylococcus aureus bacteraemia
Chapter:
Meticillin-resistant Staphylococcus aureus bacteraemia
Author(s):

James Price

DOI:
10.1093/med/9780199665754.003.0022
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date: 12 July 2020

Although rates of MRSA bacteraemia have fallen markedly in the UK, S. aureus bacteraemia remains a common clinical entity associated with substantial morbidity and mortality. This case illustrates the key elements of optimal management. Early diagnosis and prompt initiation of treatment are crucial. Unless the infection is known to be caused by MRSA, treatment should include a beta-lactam drug where possible. It is not established whether using combination antibiotic therapy improves outcome. Foci of infection must be identified promptly by thorough and repeated clinical examination and radiological investigation and removed as soon as possible. Current best evidence indicates that patients with S. aureus bacteraemia should receive intravenous treatment for a minimum of 2 weeks, with this duration increasing to 4–6 weeks in patients with endocarditis or unremovable foci of infection.

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