- Dedication
- Preface
- Experts
- Contributors
- Abbreviations
- Reference Intervals
- Case 1 Pyrexia of unknown origin: the use of PET and PET-CT
- Case 2 Neurological complications of Lyme borreliosis
- Case 3 Leptospirosis and its complications
- Case 4 Secondary syphilis
- Case 5 HIV-associated multicentric Castleman’s disease
- Case 6 HIV and prevention of mother-to-child transmission
- Case 7 HIV: antiretroviral treatment and emergence of resistance
- Case 8 HIV: opportunistic infections and immune reconstitution
- Case 9 HIV: cryptococcal meningitis and timing of antiretroviral treatment
- Case 10 Candida infection in the intensive care unit
- Case 11 Disseminated aspergillosis after bone marrow transplantation
- Case 12 Hepatitis B reactivation
- Case 13 Developments in the treatment of hepatitis C virus infection
- Case 14 Management of viral haemorrhagic fevers in the UK
- Case 15 Tropical liver abscess: diagnosis and management
- Case 16 Severe falciparum malaria: treatment options in the UK
- Case 17 Imported Plasmodium vivax
- Case 18 Typhoid fever: antibiotic treatment choices
- Case 19 Hospital-acquired Legionella pneumonia
- Case 20 Severe Clostridium difficile infection
- Case 21 Staphylococcal prosthetic joint infection
- Case 22 Meticillin-resistant Staphylococcus aureus bacteraemia
- Case 23 Pneumococcal meningitis: antibiotic options for resistant organisms
- Case 24 Urinary sepsis: vancomycin-resistant enterococci
- Case 25 Disseminated nocardiosis
- Case 26 Urinary sepsis: extended spectrum β-lactamase-producing E. coli
- Case 27 Multidrug-resistant Pseudomonas aeruginosa infection in cystic fibrosis
- Case 28 The treatment of Mycobacterium abscessus lung disease
- Case 29 Multidrug-resistant tuberculosis
- Case 30 Diagnostic and management issues in tuberculous meningitis
- Case 31 Treated pulmonary tuberculosis complicated by sarcoidosis
- Index
(p. 227) Staphylococcal prosthetic joint infection
- Chapter:
- (p. 227) Staphylococcal prosthetic joint infection
- Author(s):
Kate El Bouzidi
- DOI:
- 10.1093/med/9780199665754.003.0021
Prosthetic joint infection (PJI) is a catastrophic complication and the majority of cases are caused by coagulase-negative staphylococci or Staphylococcus aureus. Staphylococci adhere to native bone and prostheses and can form biofilms to protect against the host immune response and antibiotic penetration. Diagnosis may be difficult in the absence of fever and raised inflammatory markers, and radiology findings are often non-specific. A microbiological diagnosis may be obtained by tissue cultures or newer techniques such as sonication and PCR. The infection in the case was identified as methicillin-sensitive Staphylococcus aureus (MSSA). Different surgical strategies available to manage prosthetic joint infection are discussed including one- and two-stage revision arthroplasty, DAIR (debridement, antibiotics, and implant retention), and the use of antibiotic-eluting spacers and cement. There is controversy regarding the choice, duration, and route of administration of antibiotic therapy and whether prolonged systemic therapy is required at all. PJI creates a significant economic burden and infection control procedures are imperative to reduce the impact on patients and healthcare resources.
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- Dedication
- Preface
- Experts
- Contributors
- Abbreviations
- Reference Intervals
- Case 1 Pyrexia of unknown origin: the use of PET and PET-CT
- Case 2 Neurological complications of Lyme borreliosis
- Case 3 Leptospirosis and its complications
- Case 4 Secondary syphilis
- Case 5 HIV-associated multicentric Castleman’s disease
- Case 6 HIV and prevention of mother-to-child transmission
- Case 7 HIV: antiretroviral treatment and emergence of resistance
- Case 8 HIV: opportunistic infections and immune reconstitution
- Case 9 HIV: cryptococcal meningitis and timing of antiretroviral treatment
- Case 10 Candida infection in the intensive care unit
- Case 11 Disseminated aspergillosis after bone marrow transplantation
- Case 12 Hepatitis B reactivation
- Case 13 Developments in the treatment of hepatitis C virus infection
- Case 14 Management of viral haemorrhagic fevers in the UK
- Case 15 Tropical liver abscess: diagnosis and management
- Case 16 Severe falciparum malaria: treatment options in the UK
- Case 17 Imported Plasmodium vivax
- Case 18 Typhoid fever: antibiotic treatment choices
- Case 19 Hospital-acquired Legionella pneumonia
- Case 20 Severe Clostridium difficile infection
- Case 21 Staphylococcal prosthetic joint infection
- Case 22 Meticillin-resistant Staphylococcus aureus bacteraemia
- Case 23 Pneumococcal meningitis: antibiotic options for resistant organisms
- Case 24 Urinary sepsis: vancomycin-resistant enterococci
- Case 25 Disseminated nocardiosis
- Case 26 Urinary sepsis: extended spectrum β-lactamase-producing E. coli
- Case 27 Multidrug-resistant Pseudomonas aeruginosa infection in cystic fibrosis
- Case 28 The treatment of Mycobacterium abscessus lung disease
- Case 29 Multidrug-resistant tuberculosis
- Case 30 Diagnostic and management issues in tuberculous meningitis
- Case 31 Treated pulmonary tuberculosis complicated by sarcoidosis
- Index