Show Summary Details
Page of

Severe Clostridium difficile infection 

Severe Clostridium difficile infection
Severe Clostridium difficile infection

Jasmin Islam

Page of

PRINTED FROM OXFORD MEDICINE ONLINE ( © Oxford University Press, 2022. All Rights Reserved. Under the terms of the licence agreement, an individual user may print out a PDF of a single chapter of a title in Oxford Medicine Online for personal use (for details see Privacy Policy and Legal Notice).

date: 06 July 2022

The dramatic decline in C. difficile (CDI) rates seen in the UK since 2006 and the waning of ribotype 027 should not be a reason for complacency about this disease. With the recognition of novel virulent strains of other ribotypes and an aging population it is clear that CDI diarrhoea will remain a threat to elderly patients, particularly those in hospital. This case illustrates the importance of early recognition, diagnosis, and assessment of severe CDI to ensure both optimal infection control and management. The advent of fidaxomicin represents a significant advance but important questions remain around selection of patients to receive this treatment. Faecal therapy is now supported by randomized controlled trial evidence but more extensive clinical evaluation of this approach, in particular the role of synthetic stool, is needed before it is likely to be widely adopted.

Access to the complete content on Oxford Medicine Online requires a subscription or purchase. Public users are able to search the site and view the abstracts for each book and chapter without a subscription.

Please subscribe or login to access full text content.

If you have purchased a print title that contains an access token, please see the token for information about how to register your code.

For questions on access or troubleshooting, please check our FAQs, and if you can't find the answer there, please contact us.