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Single brain metastasis from breast cancer 

Single brain metastasis from breast cancer
Chapter:
Single brain metastasis from breast cancer
Author(s):

Thankamma Ajithkumar

DOI:
10.1093/med/9780199664535.003.0006
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date: 26 January 2021

Approximately 10% of patients with breast cancer present with metastatic brain disease. The majority of these patients have multiple brain metastases (78%) and solitary metastasis occurs in 14% of patients and 8% have leptomeningeal disease. While whole brain radiotherapy remains the standard of care in multiple brain metastases, surgery is usually the initial treatment for solitary brain metastasis. However, there is no consensus on the optimal postoperative management of resected solitary metastasis. Although a number of studies report clinical benefits of loco-regional treatment in metastatic breast cancer, there is a lack of consensus on its exact role. There is no standard optimal systemic treatment for metastatic breast cancer and the choice of systemic treatment depends on various patient-related factors such as menopausal status, performance etc, and disease related factors such as HER-2 and hormonal receptor status, tumour burden etc.

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