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Solitary plasmacytoma 

Solitary plasmacytoma
Solitary plasmacytoma

Isabella Maund

and Michael Williams

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date: 26 January 2021

Solitary plasmacytoma of bone is a rare but, potentially curable tumour. The histological finding of a plasma cell neoplasm should initiate investigations to determine whether there are features of generalised disease, i.e. multiple myeloma, or whether the lesion meets diagnostic criteria for solitary plasmacytoma, as this has a crucial impact on management. Radiotherapy remains the cornerstone of treatment with the addition of surgical stabilization procedures in selected cases. There are challenges to delivering radical doses of radiation to spinal tumours. Careful attention must be paid to sparing sensitive surrounding structures and patients must be carefully counselled regarding potentially serious late-effects. Unfortunately, despite successful local therapy, the majority of patients will ultimately progress to multiple myeloma.

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