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Hodgkin lymphoma 

Hodgkin lymphoma
Chapter:
Hodgkin lymphoma
Author(s):

Isabella Maund

and Michael Williams

DOI:
10.1093/med/9780199664535.003.0026
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date: 20 August 2019

The management of early Hodgkin lymphoma is an area of evolving practice. Investigation should be aimed at fully staging and risk stratifying patients in order to guide treatment decisions. Standard treatment is a combined modality approach including involved-field radiotherapy. However, recent trials have highlighted the issue of fatal late-effects including the risks of second malignancy and cardiovascular disease attributed to radiotherapy. Treatment strategies based on chemotherapy alone have been suggested as an alternative to radiation-based treatment. Whilst chemotherapy alone may provide improved overall survival due to reduction in non-lymphoma mortality, it is associated with an increased risk of relapse requiring extensive salvage therapy and patients must be carefully counselled regarding the risks and benefit of both approaches.

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