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Soft tissue sarcoma 

Soft tissue sarcoma
Chapter:
Soft tissue sarcoma
Author(s):

Helen Hatcher

DOI:
10.1093/med/9780199664535.003.0023
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date: 20 August 2019

Osteosarcoma is the most common primary tumour of the bone. Approximately two-thirds of patients present with localised disease. Surgery followed by adjuvant chemotherapy is the standard treatment. Studies suggest that pathological fracture at diagnosis is associated with a worse prognosis, especially if the lesion is pinned, due to the potential dissemination of tumour along the bone marrow and into the blood stream. Patients with limited and potentially resectable metastases should be treated aggressively with chemotherapy and surgery. Patients with isolated lung metastases have the best prognosis after multimodality treatment and the reported 5-year survival ranges from 10-50%.

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