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Merkel cell carcinoma 

Merkel cell carcinoma
Merkel cell carcinoma

Thankamma Ajithkumar

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date: 26 January 2021

Merkel cell carcinoma (MCC) is an aggressive neuroendocrine carcinoma of the skin. Surgery followed by adjuvant radiotherapy is the standard treatment for localised disease. Without adjuvant radiotherapy, more than 40% develop local recurrence and more than 80% develop regional recurrence. Recent studies suggest that primary radiotherapy is an appropriate alternative, which yields a better cosmesis. The role of adjuvant chemotherapy is not known. A significant proportion of patients develop distant failure. There is no standard chemotherapy for patients with metastatic disease at presentation or those who develop distant metastasis during the course of illness. Current chemotherapy regime mirrors those used in small cell lung cancer.

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