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Colon cancer 

Colon cancer
Chapter:
Colon cancer
Author(s):

Debashis Biswas

and Thankamma Ajithkumar

DOI:
10.1093/med/9780199664535.003.0012
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date: 20 August 2019

Significant progress has been made in the management of colon cancer in the last decade. Improvements in surgical techniques have had a major impact on the survival. Adjuvant fluoropyrimidine chemotherapy has improved survival, especially in stage III disease. The addition of oxalipatin to fluoroprimidines improves survival further, especially in stage III patients aged less than 65 years. However, the addition of oxaliplatin should be carefully balanced against predicted tolerability and toxicity. Close postoperative follow-up helps to identify potentially radically treatable oligometastatic recurrences. Integration of targeted therapy with chemotherapy results in improvement in survival in metastatic disease.

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