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Neuroendocrine tumour 

Neuroendocrine tumour
Chapter:
Neuroendocrine tumour
Author(s):

Gaurav Kapur

DOI:
10.1093/med/9780199664535.003.0010
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date: 20 August 2019

Neuroendocrine gastro-entero-pancreatic tumours (NET) constitute a heterogeneous group of tumours arising from the neuroendocrine cells of the embryological gut. Histological diagnosis is mandatory and these tumours express immunoreactivity to panendocrine markers (e.g. chromogranin A and synaptophysis. Curative resection of the primary tumour and locoregional nodal metastases improves survival in localised disease. Even in advanced/metastatic disease, cytoreductive surgery should be considered when metastatic disease is localised or if >70% of tumour can be resected, which might improve symptoms and response to systemic therapy. Somatostatin analogs are the medical treatment of choice in function NETs. Chemotherapy has a role in metastatic grade 2/3 tumours and inoperable liver progressive liver disease. Peptide receptor targeted radiotherapy has an established role in a subset of patients. Role of TKI and mTOR inhibitors is evolving.

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