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Traumatic brain injury 

Traumatic brain injury
Chapter:
Traumatic brain injury
Author(s):

Matilde Inglese

and Elan J. Grossman

DOI:
10.1093/med/9780199664092.003.0027
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date: 09 July 2020

Traumatic brain injury (TBI) is one of the most serious public health problems facing the modern world. The ability to predict outcome for patients could be of central importance to managing TBI, because it may be possible to identify early medical and rehabilitative interventions that reduce the risk of persistent neurologic impairment. Unfortunately, however, clinical and cognitive predictors are suboptimal for this purpose, and more objective conventional imaging also exhibits significant limitations. Recent studies have focused on applying advanced imaging techniques to examine TBI. Many of the studies have yielded promising results, which suggest that these techniques have the potential to help grade tissue damage severity, track its development, provide prognostic markers for clinical outcome, and monitor response to medical and rehabilitative interventions. Nevertheless, more research is needed, since some of these techniques lack validation as diagnostic tools. Very few investigations have been conducted, most of which examined small cohorts of patients with mixed grades of TBI severity at a single time point following injury.

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