- Section 1 The development of the discipline of public health
- Section 2 Determinants of health and disease
- Section 3 Public health policies, law, and ethics
- Section 4 Information systems and sources of intelligence
- Section 5 Epidemiological and biostatistical approaches
- 5.1 Epidemiology: the foundation of public health
- 5.2 Ecological variables, ecological studies, and multilevel studies in public health research
- 5.3 Cross-sectional studies
- 5.4 Principles of outbreak investigation
- 5.5 Case–control studies
- 5.6 Cohort studies
- 5.7 Methodology of intervention trials in individuals
- 5.8 Methodological issues in the design and analysis of community intervention trials
- 5.9 Community intervention trials in high-income countries
- 5.10 Community-based intervention trials in low- and middle-income countries
- 5.11 Clinical epidemiology
- 5.12 Genetic epidemiology
- 5.13 Validity and bias in epidemiological research
- 5.14 Causation and causal inference
- 5.15 Systematic reviews and meta-analysis
- 5.16 Statistical methods
- 5.17 Measuring the health of populations: the Global Burden of Disease study methods
- 5.18 Mathematical models of transmission and control of infectious agents
- 5.19 Public health surveillance
- 5.20 Life course epidemiology and analysis
- Section 6 Social science techniques
- Section 7 Environmental and occupational health sciences
- Section 8 Major health problems
- Section 9 Prevention and control of public health hazards
- Section 10 Public health needs of population groups
- Section 11 Public health functions
(p. 599) Systematic reviews and meta-analysis
- Chapter:
- (p. 599) Systematic reviews and meta-analysis
- Author(s):
Jimmy Volmink
and Mike Clarke
- DOI:
- 10.1093/med/9780199661756.003.0118
Science, including health care and healthcare research, should be a cumulative process. New studies should take account of information from existing research when they are designed, and their findings should be interpreted in the context of other similar studies. This provides people making decisions and choices about health care with the knowledge they need from research, that has both minimized bias and maximized the power of the findings. Systematic reviews and meta-analyses provide the means to achieve this. This chapter covers the process for these forms of scientific research. It describes how to conduct the systematic reviews and meta-analyses, how to interpret them and how to appraise their reports. We outline various elements in the process, including formulation of a review question, identification of relevant studies, extraction of data, assessment of bias in included studies, synthesis of the data, interpreting the evidence and writing up and updating the review.
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- Section 1 The development of the discipline of public health
- Section 2 Determinants of health and disease
- Section 3 Public health policies, law, and ethics
- Section 4 Information systems and sources of intelligence
- Section 5 Epidemiological and biostatistical approaches
- 5.1 Epidemiology: the foundation of public health
- 5.2 Ecological variables, ecological studies, and multilevel studies in public health research
- 5.3 Cross-sectional studies
- 5.4 Principles of outbreak investigation
- 5.5 Case–control studies
- 5.6 Cohort studies
- 5.7 Methodology of intervention trials in individuals
- 5.8 Methodological issues in the design and analysis of community intervention trials
- 5.9 Community intervention trials in high-income countries
- 5.10 Community-based intervention trials in low- and middle-income countries
- 5.11 Clinical epidemiology
- 5.12 Genetic epidemiology
- 5.13 Validity and bias in epidemiological research
- 5.14 Causation and causal inference
- 5.15 Systematic reviews and meta-analysis
- 5.16 Statistical methods
- 5.17 Measuring the health of populations: the Global Burden of Disease study methods
- 5.18 Mathematical models of transmission and control of infectious agents
- 5.19 Public health surveillance
- 5.20 Life course epidemiology and analysis
- Section 6 Social science techniques
- Section 7 Environmental and occupational health sciences
- Section 8 Major health problems
- Section 9 Prevention and control of public health hazards
- Section 10 Public health needs of population groups
- Section 11 Public health functions