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The Pharmacokinetics and Clinical Therapeutics of the Antiepileptic Drugs 

The Pharmacokinetics and Clinical Therapeutics of the Antiepileptic Drugs
The Pharmacokinetics and Clinical Therapeutics of the Antiepileptic Drugs

Mark Cook

and Simon Shorvon

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date: 25 May 2022

There are 23 first and second antiepileptic drugs in current usage, 15 of which were licensed since 1989. An understanding of their pharmacokinetics and pharmacology is important for clinical therapeutics. In this chapter the following anti epileptic drugs are considered: carbamazepine, clobazam, clonazepam, eslicarbazepine, ethosuxumide, felbamate, gabapentin, lacosamide, lamotrigine, leveracetam, phenobarbital, phenytoin, primidone, oxcarbazepine, pregabalin, retigabine, rufinamide, stiripentol, tiagabine, topiramate, valproate, vigabatrin, and zonisamide. Brief details are provided of: history of drug introduction, mechanism of action, pharmacokinetic properties, drug interactions, side effects, effectiveness, indications, preparations, dosage and blood level monitoring. The information is given in a concise form to assist physicians in their clinical practice.

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