Show Summary Details
Page of

Neonatal Seizures and Infantile-Onset Epilepsies 

Neonatal Seizures and Infantile-Onset Epilepsies
Chapter:
Neonatal Seizures and Infantile-Onset Epilepsies
Author(s):

Elia Pestana Knight

and Ingrid E.B. Tuxhorn

DOI:
10.1093/med/9780199659043.003.0014
Page of

PRINTED FROM OXFORD MEDICINE ONLINE (www.oxfordmedicine.com). © Oxford University Press, 2022. All Rights Reserved. Under the terms of the licence agreement, an individual user may print out a PDF of a single chapter of a title in Oxford Medicine Online for personal use (for details see Privacy Policy and Legal Notice).

date: 25 May 2022

In the different sections of this chapter the authors review the current knowledge about neonatal seizures and highlight the areas where there is clear controversy. The chapter begins with the epidemiology and definition of neonatal seizures. It continues with the controversies surrounding whether neonatal seizures should be classified with the epilepsies and epileptic syndrome or independently because not all the patients with neonatal seizures will develop epilepsy. The next section includes a clinical description of neonatal seizures; taking into account its phenomenology (subtle seizures, tonic seizures, clonic seizures and myoclonic seizures). A brief definition of neonatal status epilepticus is also included in this chapter. The following section covers the electroencephalographic biomarkers and characteristics of the ictal and interictal discharges in neonates. This section is followed by the risk factors and etiologies associated to or leading to neonatal seizures. The unique physiopathology of neonatal seizures is highlighted and is next followed by another controversial topic: are seizures per se, dangerous to the developing brain. Management of neonatal seizures still relies on the efficacy of phenobarbital and phenytoin as first line drugs. Secondary line drugs and other novel treatments are highlighted in the treatment section. Morbidity and mortality still remains relatively high for neonates with seizures despite advances in neonatal care in the last 20 years. A section on prognosis of neonatal seizures offers a detailed review of the medical literature documenting this data. The last section briefly describes two idiopathic epilepsy syndromes and two devastating epileptic encephalopathies that begin in the neonatal period.

Access to the complete content on Oxford Medicine Online requires a subscription or purchase. Public users are able to search the site and view the abstracts for each book and chapter without a subscription.

Please subscribe or login to access full text content.

If you have purchased a print title that contains an access token, please see the token for information about how to register your code.

For questions on access or troubleshooting, please check our FAQs, and if you can't find the answer there, please contact us.