Show Summary Details
Page of

Neurochemistry of Epilepsy 

Neurochemistry of Epilepsy
Chapter:
Neurochemistry of Epilepsy
Author(s):

B. Keith Day

, Lawrence Eisenman

, and R. Edward Hogan

DOI:
10.1093/med/9780199659043.003.0003
Page of

PRINTED FROM OXFORD MEDICINE ONLINE (www.oxfordmedicine.com). © Oxford University Press, 2016. All Rights Reserved. Under the terms of the licence agreement, an individual user may print out a PDF of a single chapter of a title in Oxford Medicine Online for personal use (for details see Privacy Policy and Legal Notice).

date: 17 January 2020

Epileptic seizures in the human brain are largely driven by neurochemical changes. The hypothesis that seizures arise from an imbalance in excitation and inhibition in the brain refers to an alteration in the balance between the major corresponding neurotransmitter systems, glutamate and γ-aminobutyric acid (GABA), respectively. Both have complex synthesis, release, receptor activation, uptake, and repletion all of which may have significant roles in the pathophysiological neuronal excitability underlying epilepsy, and are prominently involved in the neuroanatomical structures that tend to be epileptogenic. Many animal models manipulate these systems to produce seizures for neurochemical studies that provide support for the importance of glutamate and GABA in epilepsy. Human microdialysis studies have shown dynamic changes in glutamate and GABA before and during seizures and inspired the use of other technologies to complement these findings. The roles of the other major neurotransmitter systems in epilepsy are also reviewed. Finally, the neurochemistry of epilepsy provides a basis for antiepileptic drug efficacy, rational drug design, and rational polypharmacy. However, we also provide an example where clinical experience with applying these lessons produced unexpected results, showing that the complexities of epilepsy and its treatment continues to intrigue and inspire us to continue further investigations.

Access to the complete content on Oxford Medicine Online requires a subscription or purchase. Public users are able to search the site and view the abstracts for each book and chapter without a subscription.

Please subscribe or login to access full text content.

If you have purchased a print title that contains an access token, please see the token for information about how to register your code.

For questions on access or troubleshooting, please check our FAQs, and if you can't find the answer there, please contact us.