Show Summary Details
Page of

Neurophysiology of Epilepsy 

Neurophysiology of Epilepsy
Neurophysiology of Epilepsy

Florin Amzica

Page of

PRINTED FROM OXFORD MEDICINE ONLINE ( © Oxford University Press, 2021. All Rights Reserved. Under the terms of the licence agreement, an individual user may print out a PDF of a single chapter of a title in Oxford Medicine Online for personal use (for details see Privacy Policy and Legal Notice).

date: 07 May 2021

This chapter is devoted to defining some of the mechanisms that determine the behaviour of cellular membranes, both of neurons and glial cells, during the transition towards epileptic discharges and henceforth during seizures. We take the view that epileptic events are not the sole result of concerted populations of neurons, but equally important, of the dialogue between neurons, glial cells and, especially their extracellular environment. We insist on the fact that during some types of seizures, especially the ones of the grand mal type, the hypersynchronization of cerebral territories is not likely to be the work of cortical synaptic linkages because extracellular calcium levels are critically low and would not endow neuronal networks with the necessary synaptic strength. On the other hand, networks of glial cells easily communicate through gap junctions over large territories and are the main synchronizer of epileptic events. Here we emphasize the role of the extracellular potassium in signalling and modulating the glial and neuronal membranes. The chapter also includes some thoughts about the role of the cortex in starting seizures and puts it into perspective with respect to centrencephalic theories.

Access to the complete content on Oxford Medicine Online requires a subscription or purchase. Public users are able to search the site and view the abstracts for each book and chapter without a subscription.

Please subscribe or login to access full text content.

If you have purchased a print title that contains an access token, please see the token for information about how to register your code.

For questions on access or troubleshooting, please check our FAQs, and if you can't find the answer there, please contact us.