Show Summary Details
Page of

Primary ciliary dyskinesia 

Primary ciliary dyskinesia
Primary ciliary dyskinesia

Claire Hogg

Page of

PRINTED FROM OXFORD MEDICINE ONLINE ( © Oxford University Press, 2016. All Rights Reserved. Under the terms of the licence agreement, an individual user may print out a PDF of a single chapter of a title in Oxford Medicine Online for personal use (for details see Privacy Policy and Legal Notice).

date: 15 December 2019

Primary ciliary dyskinesia (PCD) is an inherited disorder affecting the structure and function of the motile cilia which line the entire respiratory tract. Damage to the structure of cilia disrupts the co-ordination of their beat pattern and results in accumulation of mucus and potential pathogens. Early signs are inability to clear foetal lung liquid at birth, situs inversus resulting from ciliary failure during embryogenesis and early onset of rhinitis and wet cough. Screening for PCD, using nasal nitric oxide measurement, is both available and highly sensitive but definitive diagnosis involves a combination of functional assessments, using ciliary beat analysis, structural assessment of the ciliary axonemal proteins using transmission electron microscopy and in some cases genotyping. Management of PCD requires regular specialist multi-system review and an aggressive approach to airway clearance. Dedicated PCD clinics should incorporate same day access to ENT and audiology, specialist physiotherapy, nursing and lung function testing.

Access to the complete content on Oxford Medicine Online requires a subscription or purchase. Public users are able to search the site and view the abstracts for each book and chapter without a subscription.

Please subscribe or login to access full text content.

If you have purchased a print title that contains an access token, please see the token for information about how to register your code.

For questions on access or troubleshooting, please check our FAQs, and if you can't find the answer there, please contact us.