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James R. Burrell

and John R. Hodges

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date: 08 May 2021

Cognitive neurology has exploded over the last century, and especially over the last 20 years. From the distinction of dementia as a pathological entity, rather than just ‘normal’ ageing, to more sophisticated sub-classification of dementia syndromes, much has been learned, though great challenges remain. From an incredible array of worthy research studies, ten landmark papers in the field of dementia are presented in this chapter. With regard to Alzheimer’s disease, the following are discussed: the initial description of the disease, both clinically and pathologically; the development of meaningful clinical assessment measures; the early clinical manifestations and genetic causes; the precursors to symptomatic treatment; the use of neuroimaging to identify amyloid pathology in vivo; and the staging of Alzheimer’s pathology. The clinical features and genetic causes of frontotemporal dementia, an important non-Alzheimer’s primary dementia syndrome seen especially in younger patients, are also discussed.

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