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Drugs affecting platelets and coagulation 

Drugs affecting platelets and coagulation
Drugs affecting platelets and coagulation

Nay Min Htun

, Ulrike Flierl

, and Karlheinz Peter

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date: 05 July 2020

Arterial and venous thromboses are very common in clinical practice and can lead to potentially catastrophic consequences such as stroke, myocardial infarction and pulmonary embolism (PE). There are many drugs available to prevent and treat thrombotic diseases and the list is growing rapidly. Drugs such as antiplatelet agents and anticoagulants are used to prevent the initiation or propagation of thrombotic events whilst fibrinolytic drugs are used to dissolve pre-existing thrombus. This chapter describes the essential features of commonly used antithrombotic and fibrinolytic drugs, including mechanisms of action, pharmacokinetics, clinical use, contraindications, side effects, and monitoring as appropriate. In addition, management of patients with over-anticoagulation as well as perioperative management of patients, who are already on antithrombotic drugs are also discussed in accordance with currently available evidence and guidelines.

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