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Clotting mechanisms and haemophilias 

Clotting mechanisms and haemophilias
Chapter:
Clotting mechanisms and haemophilias
Author(s):

Ulrike Flierl

, Nay Min Htun

, and Karlheinz Peter

DOI:
10.1093/med/9780199658220.003.0006
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date: 18 October 2019

Haemostasis has developed as a complex system requiring a fine balance of many components. If this balance is disturbed the consequences can be disastrous, resulting in inappropriate thrombosis and/ or bleeding. The components of the haemostatic system include the coagulation factors and inhibitors, as well as fibrinolytics and inhibitors, but also cellular contributors, such as platelets. The endothelium plays a pivotal role in maintaining haemostasis. These mechanisms are highly interrelated. The role of platelets and endothelium, clotting factors, natural clotting inhibitors, and natural fibrinolytics will be discussed. In addition, various assays for monitoring clotting factors and platelet function, and their therapeutic inhibition are described. The second part of the chapter deals with haemophilias, their clinical presentation, and the important issues to be considered in situations where a coagulation disorder is suspected.

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