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Chronic lower limb ischaemia: therapeutic angiogenesis 

Chronic lower limb ischaemia: therapeutic angiogenesis
Chronic lower limb ischaemia: therapeutic angiogenesis

Edward Choke

and Mark McCarthy

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date: 14 July 2020

Despite advances in preventative medicine and surgical interventions, peripheral arterial disease remains a significant worldwide health problem. A substantial number of sufferers are not candidates for intervention due to prohibitively high operative risks or unfavourable profile of disease. New and innovative therapeutic options are being investigated. Therapeutic angiogenesis is an attractive alternative currently being advocated as a potential future treatment for peripheral vascular disease. Therapeutic angiogenesis can be induced by gene therapy, recombinant protein therapy, or cell therapy. Preclinical studies have provided encouraging results, leading to numerous efficacy, and safety studies in humans. Currently, the most important task is to evaluate this strategy in carefully designed and adequately powered, randomized-controlled phase II/III trials.

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