Show Summary Details
Page of

Restenosis in vascular surgical practice—molecular biology and strategies for prevention 

Restenosis in vascular surgical practice—molecular biology and strategies for prevention
Chapter:
Restenosis in vascular surgical practice—molecular biology and strategies for prevention
Author(s):

Thomas Koeppel

and Andreas Schober

DOI:
10.1093/med/9780199658220.003.0003
Page of

PRINTED FROM OXFORD MEDICINE ONLINE (www.oxfordmedicine.com). © Oxford University Press, 2016. All Rights Reserved. Under the terms of the licence agreement, an individual user may print out a PDF of a single chapter of a title in Oxford Medicine Online for personal use (for details see Privacy Policy and Legal Notice).

date: 22 September 2019

Neointima formation is the wound healing response of the vessel wall to acute injury, and, in contrast to atherosclerosis, develops within weeks or months, but terminates shortly after. This response is mainly characterized by the accumulation of smooth muscle cells (SMCs) and extracellular matrix. Furthermore, endothelial cells, platelets, and leukocytes play a crucial role in vascular repair and neointimal growth by regulating endothelial repair and the inflammatory response. In-stent restenosis, stenosis of venous and prosthetic bypass grafts, arteriovenous fistulae, and grafts following dialysis access surgery are the main clinical situations in which neointima formation is the predominant pathology. Implantation of stents, which release anti-proliferative drugs can reduce the risk for restenosis by inhibiting neointima formation. However, impaired re-endothelialization is a major drawback of drug-eluting stents due to the risk of late stent thrombosis and neo-atherosclerosis.

Access to the complete content on Oxford Medicine Online requires a subscription or purchase. Public users are able to search the site and view the abstracts for each book and chapter without a subscription.

Please subscribe or login to access full text content.

If you have purchased a print title that contains an access token, please see the token for information about how to register your code.

For questions on access or troubleshooting, please check our FAQs, and if you can't find the answer there, please contact us.