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Primary and secondary prevention strategies in atherosclerosis 

Primary and secondary prevention strategies in atherosclerosis
Chapter:
Primary and secondary prevention strategies in atherosclerosis
Author(s):

Stephen J. Nicholls

DOI:
10.1093/med/9780199658220.003.0002
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date: 16 September 2019

Atherosclerotic cardiovascular disease is the leading cause of mortality worldwide. Over the course of the last three decades, large-scale clinical trials have established that medical interventions that target major cardiovascular risk factors have a beneficial effect on clinical event rates in the settings of primary and secondary prevention. Despite widespread use of these therapies, there remains a substantial residual risk of clinical events. This highlights the need for more intensive risk factor modification and development of new approaches to the prevention of cardiovascular disease. The current approach to risk stratification and treatment of patients and potential targets for development of new therapies will be reviewed.

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