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Craniospinal malignancies 

Craniospinal malignancies
Craniospinal malignancies

Puneet Plaha

, Allyson Parry

, Pieter Pretorius

, Michael Brada

, Olaf Ansorge

, and Claire Blesing

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date: 14 July 2020

This chapter covers cancer of the central nervous system (CNS), including epidemiology and aetiology, classification, pathology and molecular genetics, clinical manifestation, neuroradiology, medical management, surgery for intracranial tumours, radiotherapy, chemotherapy, and clinical management of brain tumours. In addition, there are sections devoted to brain and spinal metastases, and primary tumours of the skull and spine. New concepts of molecular oncology for diagnosis and therapy are discussed. Brain cancers (gliomas) were amongst the first neoplasms subjected to systematic genomic and transcriptomic analysis that may guide individualized treatments. In addition to gliomas, rarer type of intracranial tumours are included, such as ependymomas, primitive neuroectodermal tumours, and pineal tumours are also covered.

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