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Malignant lymphomas 

Malignant lymphomas
Chapter:
Malignant lymphomas
Author(s):

Frank Kroschinsky

, Friedrich Stölzel

, Stefano A. Pileri

, Björn Chapuy

, Rainer Ordemann

, Christian Gisselbrecht

, Tim Illidge

, David C. Hodgson

, Mary K. Gospodarowicz

, Christina Schütze

, and Gerald Wulf

DOI:
10.1093/med/9780199656103.003.0054
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date: 19 August 2019

Malignant lymphomas represent neoplasias arising from the peripheral lymphatic tissues in lymph nodes and extranodal sites. Classification in Hodgkin’s (HL) and non-Hodgkin’s lymphomas (NHL), B- or T-cell origin, nodal or extranodal involvement, and indolent or aggressive diseases gives a basic algorithm for clinical management. The introduction of positron emission tomography (PET) using 18F-Fluoro-deoxyglucose (18F-FDG) both alone or in combination with CT or MRI (PET/CT) improved accuracy of staging procedures and increasingly influence treatment algorithms. Current treatment options include classic cytotoxic drugs and radiotherapy and have been expanded by monoclonal antibodies, agents targeting signalling pathways and transplant procedures during the last two decades. Using this arsenal about 90% of patients with Hodgkin’s lymphomas and 60–80% of patients with aggressive B-NHL can be cured today.

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