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Pancreatic cancer 

Pancreatic cancer
Pancreatic cancer

Jürgen Weitz

, Markus W. Büchler

, Paul D. Sykes

, John P. Neoptolemos

, Eithne Costello

, Christopher M. Halloran

, Thilo Hackert

, Frank Bergmann

, Peter Schirmacher

, Ulrich Bork

, Stefan Fritz

, Jens Werner

, Thomas B. Brunner

, Elizabeth Smyth

, David Cunningham

, Brian R. Untch

, and Peter J. Allen



Expanded to incorporate a new section on the potential usefulness of glypican-1 as a marker of pancreatic cancer

Includes an updated view on IPMN management as precursor lesions for pancreatic cancer

Also gives an update on neoadjuvant therapy in pancreatic cancer

Updated on 25 May 2017. The previous version of this content can be found here.
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date: 31 July 2021

Pancreatic cancer comprises of several different exocrine and endocrine malignant diseases. The most common form is pancreatic adenocarcinoma, the tenth most common solid cancer in most of Western countries, which is discussed in this chapter. The lifetime risk of developing such a disease is 1.5%, with a mean age of diagnosis in the seventh decade. Unfortunately, no specific symptoms of this disease exist. Typically, patients present with unspecific abdominal discomfort, weight loss, and early satiety. More specific symptoms are painless jaundice and signs of endocrine or exocrine pancreatic insufficiency. Management of pancreatic cancer is complex and should best be performed by a multidisciplinary team. The individual components of such an approach are described in this chapter.

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