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Cell cycle control 

Cell cycle control
Chapter:
Cell cycle control
Author(s):

Simon M. Carr

and Nicholas B. La Thangue

DOI:
10.1093/med/9780199656103.003.0004

May 25, 2017: This chapter has been re-evaluated and remains up-to-date. No changes have been necessary.

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date: 23 October 2019

All cells arise by the division of existing cells in a highly regulated series of events known as the cell cycle. Whilst duplication of other cellular contents occurs throughout all stages of the cycle, chromosomal DNA is replicated only once at a stage known as S phase. Once this is complete, distribution of chromosomes and other cellular components occurs during the final stage of the cell cycle, known as M phase, or mitosis. The cell cycle is therefore regulated in a temporal fashion, so that entry into subsequent cell cycle stages only occurs once the previous stage has been completed. A number of signalling mechanisms monitor the integrity of cell cycle progression, and later cell cycle stages can be delayed if any errors need correction. This chapter gives an overview of the major control mechanisms that regulate cell cycle progression, and how these are circumvented during the onset of cancer.

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