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Gastric cancer 

Gastric cancer
Chapter:
Gastric cancer
Author(s):

Hideaki Bando

, Takahiro Kinoshita

, Yasutoshi Kuboki

, Atsushi Ohtsu

, and Kohei Shitara

DOI:
10.1093/med/9780199656103.003.0037
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date: 23 October 2019

This chapter covers gastric cancers, beginning with epidemiology and molecular biology, including the association between Helicobacter pylori infection and gastric cancer, and other genetic and environmental causes. The role of surgical therapy in the treatment of gastric cancer including staging and resection with curative intent is presented. The medical management of gastric cancer is discussed, including adjuvant therapy after curative surgery and systemic treatment for palliation of metastatic disease, taking into account the differing biology and treatments in the East and West. The use of the first biologics in gastric cancer, trastuzumab and ramucirumab, and their mechanisms of action are described. Various modes of palliation of symptoms in patients with advanced gastric cancer include: gastrojejunostomy, endoscopic placement of a self-expandable metallic stent for gastric stenosis or obstruction, and pain control with pain medications and radiotherapy.

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