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Growth factors and uncontrolled proliferation 

Growth factors and uncontrolled proliferation
Growth factors and uncontrolled proliferation

Shujuan Liu

and Ahmed Ashour Ahmed



Includes a new section on vascular endothelial growth

Targeted therapy of each growth factor has been updated according to the latest evidence

Limitations and future research directions of targeted therapy of growth factors have also been included

Updated on 25 May 2017. The previous version of this content can be found here.
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date: 08 July 2020

A mandatory requirement of normal growth and development is the tight spatial and temporal synchronization of cellular proliferation within a specific tissue type and between tissue types that make up an organ, a process that is governed by intrinsic and extrinsic regulatory pathways. For a cell to synchronize its growth with that of other cells it requires a network of proteins that can sense external cues, send internal messages, and produce extracellular messengers that feed back information to neighbouring cells. Growth factors act as cellular messengers to feed back regulatory signals that modulate the cell’s own behaviour (autocrine signals) and that of other adjacent cells (paracrine signals). These proteins regulate a myriad of other cellular activities. In this chapter we discuss how different growth factors relay messages to cells and describe how their deregulation contributes to the development of uncontrolled proliferation and cancer.

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