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Chris Boshoff

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date: 08 July 2020

This chapter covers the relationship between viruses and cancer, which account for up to 15% of all human cancers. It discusses the aetiology of cancer regarding herpesviruses, Epstein-Barr virus (EBV), Burkitt lymphoma (BL), nasopharyngeal carcinoma (NPC), Hodgkin disease (HD), post-transplant lymphoproliferative disorder (PTLD), Kaposi’s sarcoma-associated herpesvirus (KSHV), Multicentric Castleman’s Disease (MCD), papillomaviruses (HPV), Human T-cell Leukemia virus 1 (HTLV-1), Hepatitis B virus (HBV), Hepatocellular carcinoma (HCC), Hepatitis C virus (HCV), Merkel cell polyomavirus (MCV), and Merkel cell carcinoma (MCC). Many of these are associated with viral infections are preventable, either at an individual level or societally, and are more common in immunocompromised individuals. Worldwide, particularly in underdeveloped countries, the greatest impact on global cancer health would be on the reduction or elimination of virally-associated hepatocellular cancer and cervical cancer by immunization for HBV and HPV.

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