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Cancer and metabolism 

Cancer and metabolism
Chapter:
Cancer and metabolism
Author(s):

Cameron Snell

, Kevin C. Gatter

, Adrian L. Harris

, and Francesco Pezzella

DOI:
10.1093/med/9780199656103.003.0013_update_001

Updates

Updated to include the Oxidative Tumours and details about the uptake and use of extracellular proteins as regulated by mTORC1

Describes the role of extracellular lactate in altering the tumour microenvironment, such as macrophage and T cell differentiation and its use by tumour cells to facilitate growth

Also includes how tumours degrade tryptophan to promote an immune-permissive environment and opportunities to inhibit this pharmacologically

Updated on 25 May 2017. The previous version of this content can be found here.
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date: 23 October 2019

This chapter covers the relationship between cancer and metabolism. It discusses the role of angiogenesis and metabolic reprogramming in influencing tumour growth. The transcription factors that orchestrate the metabolic switch are discussed. The chapter presents an overview of the contribution of tumour suppressors to increased glycolysis. The metabolic changes that support uncontrolled proliferation such as lactate and pH levels, hypoxia, and reactive oxygen species are discussed. The chapter also covers the contribution of metabolic genes with oncogenic or tumour suppressor activity to metabolic transformation, the upregulation of lipid biosynthesis in cancer, and glycogen synthesis in cancer. The chapter concludes with a description of the potential strategies for targeting metabolic transformation.

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