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Cancer, immunity, and inflammation 

Cancer, immunity, and inflammation
Chapter:
Cancer, immunity, and inflammation
Author(s):

Campbell S.D. Roxburgh

and Donald C. McMillan

DOI:
10.1093/med/9780199656103.003.0012_update_001

Updates

References have been updated in ‘Introduction to cancer, immunity, and inflammation’ to highlight advances in cancer immunotherapies

‘Local immune and inflammatory responses’ has been updated reflecting recent advances in the field, including the identification of key immunosuppressive mechanisms in cancer

‘Therapeutic intervention in immune and inflammatory responses’ has been expanded and now includes data from recent trials of immunotherapies.

Updated on 25 May 2017. The previous version of this content can be found here.
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date: 24 August 2019

The chapter focuses on the role of immunity and inflammation in established cancer. From the evidence reviewed it is clear that immune and inflammatory responses, innate, humoral and adaptive, local and systemic, are intimately linked to the tumour and themselves and impact on cancer survival. It is also possible to identify key mediators that may be targeted in the cancer patient. However, further work is required to elucidate the mechanisms by which these immune and inflammatory responses are activated, maintained, and interact. Therapeutic intervention using non-selective anti-inflammatory agents is widely advocated and likely to become part of routine clinical practice in the near future. Selective therapeutic intervention directed at the immune and inflammatory responses in cancer is in its infancy. Therefore, it would appear that, at least in non-hereditary disease, immune and inflammatory responses are of key, if not of prime, importance in tumour progression and dissemination.

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