Show Summary Details
Page of

Biology of cancer and metastasis stem cells 

Biology of cancer and metastasis stem cells
Biology of cancer and metastasis stem cells

Andreas Trumpp

and Irène Baccelli

Page of

PRINTED FROM OXFORD MEDICINE ONLINE ( © Oxford University Press, 2020. All Rights Reserved. Under the terms of the licence agreement, an individual user may print out a PDF of a single chapter of a title in Oxford Medicine Online for personal use (for details see Privacy Policy and Legal Notice).

date: 07 July 2020

Regenerative tissues such as the skin epidermis, the gastrointestinal mucosa, or the haematopoietic system are maintained by the activity of rare stem cells, which sit at the helm of the cellular hierarchy of these tissues. Moreover, in response to injury signals, the tissue stem cells are activated and become critical for tissue repair. In analogy to the normal situation, many haematopoietic malignancies and carcinomas are also hierarchically organized with a cancer stem cell (CSC) at the top which is responsible for tumour growth and progression. Dissemination of CSCs from the primary tumour into the blood circulation leads to colonization and metastasis formation in distant organs. CSCs show increased resistance to chemotherapy and radiation and surviving CSCs after therapy (minimal residual disease) are thought to be the cellular source for disease relapse and metastases. Targeting and elimination of the entire CSC pool is required for long-term cure from the disease.

Access to the complete content on Oxford Medicine Online requires a subscription or purchase. Public users are able to search the site and view the abstracts for each book and chapter without a subscription.

Please subscribe or login to access full text content.

If you have purchased a print title that contains an access token, please see the token for information about how to register your code.

For questions on access or troubleshooting, please check our FAQs, and if you can't find the answer there, please contact us.