Oxford Textbook of Oncology

Oxford Textbook of Oncology (3 edn)

Edited by David J. Kerr, Daniel G. Haller, Cornelis J. H. van de Velde, and Michael Baumann

Abstract

This new 3rd edition of the Oxford Textbook of Oncology is a major piece of scholarly work that details the evolution, evidence base and current best practice in multidisciplinary practice in oncology. Oncology is the largest hospital multi-specialty and the contributors to this 3rd edition are all internationally recognised key opinion leaders in their field. It includes all aspects of oncology, including surgery, radiotherapy, and medical oncology. It focuses on the clinical aspects of oncology while also covering the basic sciences. It provides introductory chapters covering basic science (cell and molecular biology and genetics), translational science (pharmacology, pharmo-genetics, drug discovery, drug development, radiation oncology), general principles of surgical radiation and medical oncology, cancer imaging and pathology, followed by a series of disease-associated chapters.

Latest update
The 2019 update of the Oxford Textbook of Oncology has had approximately 30% of chapters reviewed by their authors to ensure accuracy. Eight chapters have had content updated to include the latest information on evidence, research, recommendations, and treatment, and the terminology and references have been amended where relevant.

Bibliographic Information

Publisher:: Oxford University Press

Print Publication Date:: Jan 2016

Print ISBN-13:: 9780199656103

Published online:: Jan 2016

DOI:: 10.1093/med/9780199656103.001.0001

Authors

David J. Kerr, editor Nuffield Division of Clinical and Laboratory Sciences, University of Oxford, UK

Daniel G. Haller, editor Perelman School of Medicine, University of Pennsylvania, Philadelphia, USA

Cornelis J. H. van de Velde, editor Professor of Surgery and Head, Department of Surgical Oncology, Leiden University Medical Center, The Netherlands

Michael Baumann, editor Cancer Research Center (DKFZ), Heidelberg, Germany and Department of Radiotherapy and Radiation Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Germany

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Disclaimer

Oxford University Press makes no representation, express or implied, that the drug dosages in this book are correct. Readers must therefore always check the product information and clinical procedures with the most up to date published product information and data sheets provided by the manufacturers and the most recent codes of conduct and safety regulations. The authors and the publishers do not accept responsibility or legal liability for any errors in the text or for the misuse or misapplication of material in this work. Except where otherwise stated, drug dosages and recommendations are for the non-pregnant adult who is not breastfeeding.

Front Matter
Section 1 Hallmarks of cancer
- Chapter 1 The hallmarks of cancer: Perspectives for cancer medicineDouglas Hanahan and Robert A. Weinberg
- Chapter 2 Growth factors and uncontrolled proliferationShujuan Liu and Ahmed Ashour Ahmed
- Chapter 3 Cell signalling pathwaysStefan Knapp
- Chapter 4 Cell cycle controlSimon M. Carr and Nicholas B. La Thangue
- Chapter 5 Cancer cell deathAmanda S. Coutts, Sandra Maniam, and Nicholas B. La Thangue
- Chapter 6 AngiogenesisYull E. Arriaga and Arthur E. Frankel
- Chapter 7 Invasion and metastasisAndrew P. Mazar, Andrey Ugolkov, Jack Henkin, Richard W. Ahn, and Thomas V. O’Halloran
- Chapter 8 Genetic instabilityJennifer Wilding and Walter Bodmer
- Chapter 9 DNA repair after oncological therapy (radiotherapy and chemotherapy)Ekkehard Dikomey, Kerstin Borgmann, Malte Kriegs, Wael Y. Mansour, Cordula Petersen, and Thorsten Rieckmann
- Chapter 10 Biology of cancer and metastasis stem cellsAndreas Trumpp and Irène Baccelli
- Chapter 11 Biomarker identification and clinical validationRichard D. Kennedy, Manuel Salto-Tellez, D. Paul Harkin, and Patrick G. Johnston
- Chapter 12 Cancer, immunity, and inflammationCampbell S.D. Roxburgh and Donald C. McMillan
- Chapter 13 Cancer and metabolismCameron Snell, Kevin C. Gatter, Adrian L. Harris, and Francesco Pezzella
Section 2 Aetiology and epidemiology of cancer
- Chapter 14 Smoking and cancerJonathan M. Samet
- Chapter 15 VirusesChris Boshoff
- Chapter 16 Chemical carcinogensPaula A. Oliveira
- Chapter 17 Radiation-induced cancerKlaus R. Trott
- Chapter 18 Aetiology and progression of cancer: Role of body fatness, physical activity, diet, and other lifestyle factorsFränzel J.B. van Duijnhoven and Ellen Kampman
Section 3 Principles of oncology
- Chapter 19 Practice points for surgical oncologyPetra G. Boelens, C.B.M. van den Broek, and Cornelis J.H. van de Velde
- Chapter 20 Practice points for radiation oncologyAnnekatrin Seidlitz, Stephanie E. Combs, Jürgen Debus, and Michael Baumann
- Chapter 21 Principles of chemotherapyDavid J. Kerr, Daniel G. Haller, and Jaap Verweij
- Chapter 22 Multidisciplinary cancer careDavid N. Church, Rachel Kerr, and David J. Kerr
- Chapter 23 Principles of clinical pharmacology: Introduction to pharmacokinetics and pharmacodynamicsMichael Ong and Udai Banerji
- Chapter 24 Design and analysis of clinical trialsDaniel J. Sargent and Qian Shi
- Chapter 25 Medical ethics in oncologyEric A. Singer
- Chapter 26 Health economic assessment of cancer therapyJeffrey Peppercorn
Section 4 Population health
- Chapter 27 Cancer control planningMassoud Samiei
- Chapter 28 Cancer prevention: VaccinationSarah E.B. Goltz and Julian Lob-Levyt
- Chapter 29 Cancer chemopreventionKatja Zirlik, Nadir Arber, and Dirk Schrijvers
- Chapter 30 Population cancer screeningAndrew Evans, C. Simon Herrington, and Robert J.C. Steele
- Chapter 31 Familial cancer syndromesCarrie L. Snyder, Heather Hampel and Henry T. Lynch
Section 5 Support for the cancer patient
- Chapter 32 Supportive and palliative careDavid Hui and Eduardo Bruera
- Chapter 33 Quality of lifeNeil K. Aaronson and Peter M. Fayers
- Chapter 34 Cancer survivorship and rehabilitationRachel L. Yung and Ann H. Partridge
Section 6 Disease orientated chapters
- Chapter 35 Head and neck cancerChristine H. Chung, Andreas Dietz, Vincent Gregoire, Marco Guzzo, Marc Hamoir, C. René Leemans, Jean-Louis Lefebvre, Lisa Licitra, Adel K. El-Naggar, Brian O’Sullivan, I. Bing Tan, Vincent Vandecaveye, Vincent Vander Poorten, Jan B. Vermorken, and Michelle D. Williams
- Chapter 36 Oesophageal cancerMelissa Thomas, Karin Haustermans, Eric Van Cutsem, Piet Dirix, Xavier Sagaert, Christophe M. Deroose, Philippe Nafteux, Hans Prenen, and Toni Lerut
- Chapter 37 Gastric cancerHideaki Bando, Takahiro Kinoshita, Yasutoshi Kuboki, Atsushi Ohtsu, and Kohei Shitara
- Chapter 38 Rectal cancer and systemic therapy of colorectal cancerRegina Beets-Tan, and Bengt Glimelius
- Chapter 39 Colorectal cancerAlex Boussioutas, Stephen B. Fox, Iris Nagtegaal, Alexander Heriot, Jonathan Knowles, Michael Michael, Sam Ngan, Kathryn Field, and John Zalcberg
- Chapter 40 Pancreatic cancerJürgen Weitz, Markus W. Büchler, Paul D. Sykes, John P. Neoptolemos, Eithne Costello, Christopher M. Halloran, Thilo Hackert, Frank Bergmann, Peter Schirmacher, Ulrich Bork, Stefan Fritz, Jens Werner, Thomas B. Brunner, Elizabeth Smyth, David Cunningham, Brian R. Untch, and Peter J. Allen
- Chapter 41 Hepatobiliary cancersGraeme J. Poston, Nicholas Stern, Jonathan Evans, Priya Healey, Daniel Palmer, and Mohandas K. Mallath
- Chapter 42 Peritoneal mesotheliomaH. Richard Alexander, Jr., Dario Baratti, Terence C. Chua, Marcello Deraco, Raffit Hassan, Marzia Pennati, Federica Perrone, Paul H. Sugarbaker, Anish Thomas, Keli Turner, Tristan D. Yan, and Nadia Zaffaroni
- Chapter 43 Cancer of the breastMartine Piccart, Toral Gathani, Dimitrios Zardavas, Hatem A. Azim, Jr., Christos Sotiriou, Giuseppe Viale, Emiel J.T. Rutgers, Mechthild Krause, Monica Arnedos, Suzette Delaloge, Fabrice Andre, and Felipe Ades Moraes
- Chapter 44 Gynaecological cancersRichard Pötter, Shujuan Liu, Bolin Liu, Sebastien Gouy, Sigurd Lax, Eric Leblanc, Philippe Morice, Fabrice Narducci, Alexander Reinthaller, Maximilian Paul Schmid, Catherine Uzan, and Pauline Wimberger
- Chapter 45 Genitourinary cancersJohn Fitzpatrick, Asif Muneer, Jean de la Rosette, and Thomas Powles
- Chapter 46 Lung cancerRafał Dziadziuszko, Michael Baumann, Tetsuya Mitsudomi, Keith M. Kerr, Solange Peters, and Stefan Zimmermann
- Chapter 47 Neoplasms of the thymusRebecca Bütof, Axel Denz, Gustavo Baretton, Jan Stöhlmacher-Williams, and Michael Baumann
- Chapter 48 Pleural mesotheliomaAndrea S. Wolf, Assunta de Rienzo, Raphael Bueno, Lucian R. Chirieac, Joseph M. Corson, Elizabeth H. Baldini, David Jackman, Ritu Gill, Walter Weder, Isabelle Opitz, Ann S. Adams, and David J. Sugarbaker
- Chapter 49 Skin cancer: melanomaJohn F. Thompson, Richard A. Scolyer, and Richard F. Kefford
- Chapter 50 Skin cancer: non-melanomaDiona L. Damian, Richard A. Scolyer, Graham Stevens, Alexander Guminski, and John F. Thompson
- Chapter 51 Acute leukaemiasAdele K. Fielding, Charles G. Mullighan, Dieter Hoelzer, Eytan M. Stein, Ghada Zakout, Martin S. Tallman, Yishai Ofran, Jacob M. Rowe, and Ross L. Levine
- Chapter 52 Chronic leukaemiasHemant Malhotra, Lalit Kumar, Pankaj Malhotra, Devendra Hiwase, and Ravi Bhatia
- Chapter 53 MyelomaCharlotte Pawlyn, Faith Davies, and Gareth Morgan
- Chapter 54 Malignant lymphomasFrank Kroschinsky, Friedrich Stölzel, Stefano A. Pileri, Björn Chapuy, Rainer Ordemann, Christian Gisselbrecht, Tim Illidge, David C. Hodgson, Mary K. Gospodarowicz, Christina Schütze, and Gerald G. Wulf
- Chapter 55 Sarcomas of soft tissues and bone and gastrointestinal stromal tumourAlessandro Gronchi, Angelo P. Dei Tos, and Paolo G. Casali
- Chapter 56 Craniospinal malignanciesPuneet Plaha, Allyson Parry, Pieter Pretorius, Michael Brada, Olaf Ansorge, and Claire Blesing
- Chapter 57 Tumours of the eye and orbitDaniel G. Ezra, Geoffrey E. Rose, Jacob Pe’er, Sarah E. Coupland, Stefan Seregard, G.P.M. Luyten, and Annette C. Moll
- Chapter 58 Endocrine cancersAndrew Weaver, Anthony P. Weetman, Oliver Gimm, Ashley Grossman, Petra Sulentic, Bertram Wiedenmann, Ursula Plöckinger, Ulrich-Frank Pape, John Wass, Angela Rogers, and Wouter de Herder
- Chapter 59 Cancer of unknown primary siteNicholas Pavlidis and George Pentheroudakis
End Matter
- Index

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Oxford Textbook of Oncology (3 edn)

Edited by David J. Kerr, Daniel G. Haller, Cornelis J. H. van de Velde, and Michael Baumann

Abstract

Bibliographic Information

Authors

Contents