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Principles of drug therapy: focus on opioids 

Principles of drug therapy: focus on opioids
Chapter:
Principles of drug therapy: focus on opioids
Author(s):

Ruth Branford

, Emily Wighton

, and Joy Ross

DOI:
10.1093/med/9780199656097.003.0091
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date: 07 May 2021

Key principles of clinical pharmacology inform prescribing in palliative care. The use of opioid therapy for pain in populations with serious medical illness exemplifies the relevance of these principles. Concepts include the differences among efficacy, effectiveness, and cost-effectiveness; the nature of a benefit-to-risk analysis; and the meaning of pharmacokinetic variation and pharmacokinetic-pharmacodynamic relationships. This information complements related information about opioid therapy, including best practices during routine care and the role of opioid switching, opioid abuse, and opioid prescribing at the end of life. More extensive information about general pharmacology is available in comprehensive pharmacology textbooks.

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