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Neurological problems in advanced cancer 

Neurological problems in advanced cancer
Neurological problems in advanced cancer

Augusto Caraceni

, Cinzia Martini

, and Fabio Simonetti

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date: 16 May 2022

Neurological complications are frequent in populations with advanced cancer. An adequate neurological assessment is always important in addressing pain, cognitive symptoms, and peripheral and central nervous system complications. This chapter discusses a variety of neurological problems found in advanced cancer together with their clinical aspects and management, including some suggested regimens for pharmacological therapy. Complications that are discussed include intracranial hypertension, seizures in patients with advanced illness (including a suggested algorithm for the management of status epilepticus), delirium, brain metastases, spinal cord compression (including an algorithm for the evaluation of back pain), leptomeningeal metastases, base of the skull and cranial nerve syndromes, and paraneoplastic neurological syndromes.

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