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Principles of white matter organization 

Principles of white matter organization
Principles of white matter organization

Marco Catani

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date: 25 July 2021

The anatomy of white matter connections is living a time of resurgence. New diffusion imaging methods to study connections in the human brain are delineating pathways that were previously unknown. The combination of these techniques with functional imaging and standardized psychological testing is defining a new functional anatomy of the principal networks underlying cognition and behaviour. There is also preliminary evidence of the clinical benefits that mapping connections may have in patients affected by neurological disorders. In this chapter the reader is first introduced to most methods employed to study white matter connections in animal and man. A general classification of white matter pathways and a brief overview of their possible correlates are provided for each tract. Finally, the contribution of white matter pathways to brain function and possible implications in cognitive and behavioural disorders are discussed.

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