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Dementia with Lewy bodies and Parkinson’s disease dementia 

Dementia with Lewy bodies and Parkinson’s disease dementia
Chapter:
Dementia with Lewy bodies and Parkinson’s disease dementia
Author(s):

Haşmet A. Hanağası

, Başar Bilgiç

, and Murat Emre

DOI:
10.1093/med/9780199655946.003.0036
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date: 02 June 2020

Dementia with Lewy bodies and Parkinson’s disease dementia are both synucleinopathies and affect cognition, behaviour, movement, and autonomic function. The main difference is the temporal sequence of symptoms; extrapyramidal symptoms precede dementia in PDD whereas they coincide with or follow dementia in DLB. The cognitive profile is characterized by particularly severe deficits in executive, visuospatial functions and attention. Prominent memory impairments may be absent in the early stages but usually appear as the disease progresses. Visual hallucinations and delusions are the most common psychiatric symptoms and are seen in most patients. The main biochemical deficit associated with these diseases is impairment in cholinergic markers; deficits in other neurotransmitters such as dopamine and serotonin are also found. Placebo-controlled randomized controlled trials with cholinesterase inhibitors rivastigmine and donepezil have shown modest but significant clinical benefits in PDD and to some extent in DLB.

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