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Frontotemporal dementia 

Frontotemporal dementia
Frontotemporal dementia

Bruce Miller

and Soo Jin Yoon

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date: 18 October 2021

Frontotemporal dementia (FTD) is a clinically, pathologically, and genetically heterogeneous group of degenerative disorders and may be associated with parkinsonian features or motor neuron disease. There are three clinical subtypes of FTD: (1) behavioural variant FTD characterized by changes in personality and behaviour where the nidus of degeneration is frontal and temporal (usually right hemisphere involvement more than left) disease; (2) nonfluent/agrammatic variant primary progressive aphasia characterized by motor-speech production impairment and agrammatism where the nidus of degeneration is left frontoinsular and basal ganglia; and (3) semantic variant primary progressive aphasia characterized by loss of knowledge about words (left anterior temporal dysfunction) and people (right anterior temporal dysfunction). bvFTD is the most common disease among these three clinical subtypes, and will be considered further in this chapter.

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