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Genetics of degenerative dementias 

Genetics of degenerative dementias
Genetics of degenerative dementias

Rita Guerreiro

and Jose Bras

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date: 28 October 2021

The aim of this chapter is to provide an overview of the genetic causes and risk factors involved in the degenerative dementias. The last decade has seen tremendous advances in genetic technologies. These have been used with great success to identify genetic causes and genetic risk for a variety of diseases. This chapter reviews the main genetic technologies currently being used and how these methods allowed for the identification of different types of genetic variability as being associated with dementias. The chapter focuses not only on Alzheimer’s disease but also discusses recent findings from frontotemporal dementia and dementia with Lewy bodies, all of which have seen great advances in our understanding of the molecular pathways involved in these diseases.

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