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Autoimmune encephalitis 

Autoimmune encephalitis
Autoimmune encephalitis

Sarosh R. Irani

, Thomas D. Miller

, and Angela Vincent

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date: 27 February 2021

This chapter describes the clinical and paraclinical features of an expanding group of conditions associated with potentially pathogenic autoantibodies. These autoantibodies target the extracellular domains of critical neuronal proteins. The associated conditions are increasingly recognized as a cause of cognitive and behavioural disturbances in children and adults, and often associate with a number of other clinical features including seizures and movement disorders. Importantly, these conditions show often marked improvements with immunotherapies. Finally, this chapter discusses the putative mechanisms underlying the pathophysiology of these conditions, the associated cognitive deficits, and MRI findings which suggest these diseases could be used for the study of broader neurosciences questions.

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