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Cognition in multiple sclerosis 

Cognition in multiple sclerosis
Chapter:
Cognition in multiple sclerosis
Author(s):

Maria A. Ron

DOI:
10.1093/med/9780199655946.003.0027
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date: 26 May 2020

Multiple sclerosis causes cognitive impairment in 40–70 per cent of all patients. Cognitive impairment may be present early in the disease and is more severe in those with a progressive course. Speed of processing information, memory, and executive functions are most commonly impaired. Fatigue, anxiety, and depression, common in MS, can influence cognitive performance. A multisystem disconnection syndrome caused by damage to white matter tracts and intrinsic cortical pathology is thought to explain the cognitive decline. Disease modifying treatments appear to have a beneficial effect of cognition as do acetylcholinesterase inhibitors. The role of cognitive remediation is less clear.

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