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Tricyclic antidepressant overdose 

Tricyclic antidepressant overdose
Tricyclic antidepressant overdose

Shwetha Rao

, and Emma Townsend

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date: 26 January 2022

This chapter provides a discussion of the challenges facing the emergency physician when dealing with a patient who is acutely unwell following an overdose of tricyclic antidepressants. It discusses the toxic effects of tricyclic antidepressants

It examines the evidence base for three key clinical questions: the appropriateness of gastric decontamination; investigations as markers of toxicity of overdose; and the use of sodium bicarbonate. The importance of ECG changes is highlighted and additional adjuvant treatments which might be used are introduced.

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