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Cardiovascular and pulmonary pharmacology 

Cardiovascular and pulmonary pharmacology
Cardiovascular and pulmonary pharmacology

David Smith

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date: 19 October 2020

Cardiovascular and pulmonary pharmacology is fundamental to the anaesthetic management of patients undergoing cardiothoracic surgery. For this reason, this chapter reviews aspects pharmacology that are relevant to anaesthesia in adults and children. The effect cardiopulmonary bypass on the pharmacokinetics of relevant drugs is reviewed. Drugs that act on the lung and airways are then outlined. Next, the pharmacology anaesthetic drugs and opioids relevant to cardiothoracic anaesthesia is covered including anaesthetic preconditioning. Finally, the pharmacology of anti-arrhythmics, positive inotropic agents, vasodilators and vasconstrictors used in cardiac anaesthesia are outlined. Drugs are listed alphabetically in each section for ease of searching, including novel inotropic agents and sedatives, with comparative data tabulated for ease of reference.

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