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The inflammatory response to cardiothoracic surgery 

The inflammatory response to cardiothoracic surgery
Chapter:
The inflammatory response to cardiothoracic surgery
Author(s):

William T. McBride

and Esther R. McBride

DOI:
10.1093/med/9780199653478.003.0005
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date: 15 October 2019

This chapter considers the inflammatory response to cardiothoracic surgery in the context of the overall immune system. The difference between a localized and systemic inflammatory response is explained and how surgically induced perturbations of the coagulation system lead to systemic modulation of the perioperative inflammatory response. The pro-inflammatory effects of procoagulations and fibrinolysis are seen as balanced by the anti-inflammatory effects of anticoagulation and antifibrinolyis. In addition, the concept of pro- and anti-inflammatory cytokine balance will also be considered and the effects of imbalance will be described in particular implications for organ dysfunction and immune responsiveness to infection. Finally, the role of the kidneys in the inflammatory response will be examined.

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