- Foreword
- Preface
- Abbreviations
- Contributors
- Chapter 1 The 2016 revision of the WHO classification of tumours of the central nervous system
- Chapter 2 Astrocytic tumours: pilocytic astrocytoma, pleomorphic xanthoastrocytoma, and subependymal giant cell astrocytoma
- Chapter 3 Astrocytic tumours: diffuse astrocytoma, anaplastic astrocytoma, glioblastoma, and gliomatosis cerebri
- Chapter 4 Oligodendroglial tumours
- Chapter 5 Ependymal tumours
- Chapter 6 Choroid plexus tumours
- Chapter 7 Other neuroepithelial tumours: astroblastoma, angiocentric glioma, and chordoid glioma
- Chapter 8 Neuronal and mixed neuronal–glial tumours
- Chapter 9 Embryonal and pineal tumours
- Chapter 10 Tumours of the cranial nerves
- Chapter 11 Meningiomas
- Chapter 12 Other tumours of the meninges
- Chapter 13 Tumours of the haematopoietic system
- Chapter 14 Germ cell tumours
- Chapter 15 Familial tumour syndromes: neurofibromatosis, schwannomatosis, rhabdoid tumour predisposition, Li–Fraumeni syndrome, Turcot syndrome, Gorlin syndrome, and Cowden syndrome
- Chapter 16 Familial tumour syndromes: von Hippel–Lindau disease
- Chapter 17 Familial tumour syndromes: tuberous sclerosis complex
- Chapter 18 Pituitary tumours
- Chapter 19 Metastatic brain tumours
- Chapter 20 Metastatic tumours: spinal cord, plexus, and peripheral nerve
- Chapter 21 Neoplastic meningitis: metastases to the leptomeninges and cerebrospinal fluid
- Index
(p. 37) Oligodendroglial tumours
- Chapter:
- (p. 37) Oligodendroglial tumours
- Author(s):
Wolfgang Wick
, Colin Watts
, and Minesh P. Mehta
- DOI:
- 10.1093/med/9780199651870.003.0004
Concepts of diagnosis and treatment of oligodendroglial tumours have changed through clinical and translational studies over recent years. Diagnosis is now based on histopathological and integrated molecular information. The latter includes mutations in isocitrate dehydrogenase and the co-deletion of 1p/19q in the tumour tissue. In parallel, the long-term evaluation of large randomized trials performed in Europe and North America led to the current standard of a more aggressive chemoradiation regimen with procarbazine, CCNU (lomustine), and vincristine to optimize progression-free and overall survival. The future directions are delineated, which are aiming at further definition of prognostic and predictive subgroups, based on clinical, molecular, and imaging parameters, integrating immunotherapeutic concepts, as well as a closer look at patient-centred outcomes in upcoming trials.
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- Foreword
- Preface
- Abbreviations
- Contributors
- Chapter 1 The 2016 revision of the WHO classification of tumours of the central nervous system
- Chapter 2 Astrocytic tumours: pilocytic astrocytoma, pleomorphic xanthoastrocytoma, and subependymal giant cell astrocytoma
- Chapter 3 Astrocytic tumours: diffuse astrocytoma, anaplastic astrocytoma, glioblastoma, and gliomatosis cerebri
- Chapter 4 Oligodendroglial tumours
- Chapter 5 Ependymal tumours
- Chapter 6 Choroid plexus tumours
- Chapter 7 Other neuroepithelial tumours: astroblastoma, angiocentric glioma, and chordoid glioma
- Chapter 8 Neuronal and mixed neuronal–glial tumours
- Chapter 9 Embryonal and pineal tumours
- Chapter 10 Tumours of the cranial nerves
- Chapter 11 Meningiomas
- Chapter 12 Other tumours of the meninges
- Chapter 13 Tumours of the haematopoietic system
- Chapter 14 Germ cell tumours
- Chapter 15 Familial tumour syndromes: neurofibromatosis, schwannomatosis, rhabdoid tumour predisposition, Li–Fraumeni syndrome, Turcot syndrome, Gorlin syndrome, and Cowden syndrome
- Chapter 16 Familial tumour syndromes: von Hippel–Lindau disease
- Chapter 17 Familial tumour syndromes: tuberous sclerosis complex
- Chapter 18 Pituitary tumours
- Chapter 19 Metastatic brain tumours
- Chapter 20 Metastatic tumours: spinal cord, plexus, and peripheral nerve
- Chapter 21 Neoplastic meningitis: metastases to the leptomeninges and cerebrospinal fluid
- Index